구강편평세포암종에서 Snail과 E-cadherin의 면역조직화학적 발현
The Immunohistochemical Expression of Snail and E-cadherin in Oral Squamous Cell Carcinoma
유미현, 육종인, 김남희, 고현석, 백정미, 박정국, 이상휘, 김현실,
소속 상세정보
유미현 ( Ryu Mi-Heon ) - 남서울대학교 치위생학과
육종인 ( Yook Jong-In ) - 연세대학교 치과대학 구강병리학교실
김남희 ( Kim Nam-Hee ) - 연세대학교 치과대학 구강종양연구소
고현석 ( Ko Hyun-Seok ) - 연세대학교 치과대학 구강종양연구소
백정미 ( Baik Jeong-Mi ) - 연세대학교 치과대학 구강종양연구소
박정국 ( Pioa Zheng-Guo ) - 연세대학교 치과대학 구강종양연구소
이상휘 ( Lee Sang-Hwy ) - 연세대학교 치과대학 구강악안면외과학교실
김현실 ( Kim Hyun-Sil ) - 연세대학교 치과대학 구강종양연구소
KMID : 0829220090330010037
Abstract
Epithelial-mesenchymal transition (EMT) can play an important role in carcinogenesis of oral squamous cell carcinoma (OSCC). EMT is characterized by morphological and phenotypical change of epithelial cells into mesenchymal cells, and transcriptional repressor of E-cadherin, Snail is critical for EMT. In order to investigate the role of Snail and E-cadherin in OSCC, we analyzed the immunohistochemical pattern of Snail and E-cadherin in 18 OSCCs. The expression of Snail in the OSCC was increased whereas the expression of E-cadherin in the OSCC was decreased in comparison with those of normal oral mucosa, showing reverse correlation. Especially, the fibroblasts near the islands of OSCC showed the positivity of Snail, suggesting the reactive fibroblasts to the EMT of epithelial tumor cells. In metastatic squamous cell carcinoma in cervical lymph node, the positivity of Snail of tumor cells was higher than that of primary OSCC. We concluded that the increased Snail expression and the decreased E-cadherin expression were involved in the progression, invasion and metastasis of OSCC.
키워드
Oral squamous cell carcinoma;Epithelial-mesenchymal transition;Snail;E-cadherin;Immunohistochemistry
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